By Nathan Brown
the 1st part serves as an creation to the subject via describing the concept that of scaffolds, their discovery, variety and illustration, and their significance for locating new chemical entities. the next half describes the most typical instruments and techniques for scaffold hopping, even if topological, shape-based or structure-based. tools corresponding to CATS, characteristic bushes, function aspect Pharmacophores (FEPOPS), and SkelGen are mentioned between many others. the ultimate half includes 3 absolutely documented real-world examples of winning drug improvement initiatives by means of scaffold hopping that illustrate some great benefits of the procedure for medicinal chemistry.
whereas lots of the case stories are taken from medicinal chemistry, chemical and structural biologists also will profit enormously from the insights offered here.
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Scaffold Hopping in Medicinal Chemistry, Volume 58 (Methods and Principles in Medicinal Chemistry) by Nathan Brown