By Thomas Nogrady,Donald F. Weaver
beginning with an summary of easy ideas, Medicinal Chemistry examines the houses of drug molecules, the features of drug receptors, and the character of drug-receptor interactions. Then it systematically examines a number of the households of receptors considering human sickness and drug layout. the 1st 3 sessions of receptors are regarding endogenous molecules: neurotransmitters, hormones and immunomodulators. subsequent, receptors linked to mobile organelles (mitochondria, telephone nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, micro organism) are tested. via this overview of receptors, all of the major different types of human ailment and all significant different types of gear are thought of.
there were many adjustments within the 3rd variation, together with a brand new bankruptcy at the immune procedure. due to their more and more popular function in drug discovery, molecular modeling recommendations, excessive throughput screening, neuropharmacology and genetics/genomics are given even more awareness. The bankruptcy on hormonal remedies has been completely up-to-date and re-organized. rising enzyme goals in drug layout (e.g. kinases, caspases) are mentioned, and up to date details on voltage-gated and ligand-gated ion channels has been integrated. The sections on antihypertensive, antiviral, antibacterial, anti inflammatory, antiarrhythmic, and anticancer medications, in addition to remedies for hyperlipidemia and peptic ulcer, were considerably increased. One new function will increase the book's entice all readers: clinical-molecular interface sections that facilitate knowing of the remedy of human affliction at a molecular level.
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Medicinal Chemistry: A Molecular and Biochemical Approach by Thomas Nogrady,Donald F. Weaver